When they leave the overturned tank, Leon and Buddy are confronted with the first two Tyrants. Outside, a third Tyrant appears Leon and Buddy decapitate it with tank fire. Leon and Buddy team up and barely make it out of the palace basement, apparently escaping the Tyrants. Svetlana activates two Tyrants to eliminate Leon, Buddy and the Lickers. Buddy arrives, sending Lickers to attack the troops. When Svetlana and her army troops surround them, Ada releases a smoke bomb and escapes, while Leon kills several soldiers. Ada escapes using a hidden knife and meets Leon at the main hive control. Leon shortly afterwards entered the bunker where Ada is held. Svetlana exposes Ada as a fraud, who is captured after a fight with Svetlana. Leon then asks Buddy to give up the Plaga, who refuses and escapes when military jets bomb the church. After Buddy arrives, he and JD share some last words and Leon kills JD. Leon returns to the church to find Ganados have attacked it, killing the other rebels and infecting JD. Ada then leaves, warning the city will soon be bombed. Leon runs into Ada, who admits she is in the country to collect a sample of Plaga and hinting at a past romantic involvement with Leon. JD helps Leon escape, urging him to stop Buddy, as he is obsessed with his hatred of the government, which bombed his school, killing his fiancГ©e and his students. JD leads Leon to a church, where they regroup with other rebels.

Leon escapes and meets JD, only for Plaga hosts to attack them. Ivan tells Buddy to kill him and Buddy reluctantly complies. Elsewhere, soldiers burst into the rebel hideout Leon tries to warn them of Ivan's infection, but Buddy starts a shoot-out. Ada explains a human infected with the virus's dominant strain will have a brief master-slave relationship with lesser BOWs. Meanwhile, President Svetlana Belikova meets Ada Wong, who is posing as a BSAA agent. Leon awakens, tied to a chair by rebel fighters J.D., the former teacher Alexander Kozachenko (Buddy), and the elderly Ivan Judanovich, the group's Ataman. He comes across his contact, who has been attacked and is then killed by a Licker after Leon is knocked out by an explosion a shadowy figure orders the Licker not to kill Leon. Determined to stop the BOWs, Leon ignores the order.

After his arrival, Ingrid Hunnigan informs him the government has ordered an immediate retreat of all U.S. Kennedy enters the Eastern Slav Republic to verify rumors that Bio-Organic Weapons (BOWs) are being used in the country's civil war.

Resident evil degeneration